@ww if you separate anything from cellulose, it becomes instant release
technically, you could give it the same treatment as it does in a human body (so, dissolve and skip any filtering) and this should speed things up (tho definitely not be equal to a pure-ish solution)
also technically, a simple gravity filter (like a coffee filter) should help immensely (never tried that tho)
i'm... assuming you know about the risks of instant release so i won't repeat myself ;p
@ww i have made a whole post, but then noticed that pseudoephedrine is (obviously) a schedule iv precursor (in my country) – technically i could still answer questions about pseudoephedrine (as only schedule i precursors are treated seriously), but i'll refrain from that and focus on the rest
microcrystalline cellulose shouldn't dissolve in water, ether, and dilute mineral acids (as it just forms clumps), but it tends to disperse (which would require filtering)
that still leaves you with some impurities; if you want it to be perfect, you get a slow filter, a bunch of silica and the hirsch or büchner funnel (obviously, with some type of vacuum connected to the flask) – it's an overkill tho
getting loratadine out of almost any combination solution will be a major headache (either compare solubilities or melting points)
i'd strongly suggest against nasal use of loratadine specifically – there's no safety data for nasal, it's mildly anticholinergic and nasal always means higher peaks (so i'd even say it's a moderate seizure risk at some doses, on top of seizure risks of any other substances involved)
ℹ️ yield can't be calculated with so many variables that are not known, most steps here are basically playing with fire, possession of pure pseudoephedrine is illegal in a bunch of countries, my advice is best effort (and definitely not perfect) and you shouldn't follow it for non-educational purposes
